The 2019 Conference on Retroviruses and Opportunistic Infections included many exciting advances in antiretroviral therapy (ART). However, late diagnosis and mortality after ART initiation remain high, even in the context of HIV service scale-up, and mortality from unintentional opioid overdose in people living with HIV in the United States is on the rise. Decreasing regional and national rates of resistance may be a benefit of increasing use of integrase strand transfer inhibitors (InSTIs). Epub 2020 Jun 15. The 2019 Conference on Retroviruses and Opportunistic Infections included many exciting advances in antiretroviral therapy (ART). EMA has recommended the granting of marketing authorisationsfor two new antiretroviral (ARV) medicines, Rekambys (rilpivirine) and Vocabria injection (cabotegravir), to be used together for the treatment of patients with human immunodeficiency virus type 1 (HIV-1) infection. Long-acting injectable antiretroviral therapy (ART) offers the convenience of reduced dosing frequency . A clinical trial to evaluate long-acting antiretroviral therapy (ART) for maintaining HIV suppression in people for whom adhering to conventional daily oral ART has been a challenge has begun at research sites across the United States. Read on to learn more about the new drug and what to consider ahead of its potential arrival in early 2021. More information: Morgan M. Philbin et al, A Qualitative Exploration of Women's Interest in Long-Acting Injectable Antiretroviral Therapy Across … 4,5,6 Cabotegravir and rilpivirine are co-administered as two intramuscular (IM) injections in the buttocks by a Healthcare Professional at the … CROI 2019: Antiretroviral Therapy Volume 27 Issue 1 April 2019 against a broad range of HIV-1 resistant to other ART classes including those with Gag polymorphisms conferring resistance to maturation inhibitors. COVID-19 is an emerging, rapidly evolving situation. The ATLAS-2M study examined reducing the frequency of dosing from 4-weekly to 8-weekly, the findings of which are reported by Edgar Overton and colleagues in . The global ATLAS (Antiretroviral Therapy as Long-Acting Suppression) and FLAIR (First Long-Acting Injectable Regimen) pivotal phase 3 studies included more than 1,100 patients from 16 countries and concluded that the combination of cabotegravir and rilpivirine, injected monthly, was as effective as a daily, oral, three-drug regimen in maintaining viral suppression throughout the 48-week study period. Test-and-treat … Author information: … The … Awareness about and willingness to use long-acting injectable pre-exposure prophylaxis (LAI-PrEP) among people who use drugs. 2019 Oct;311-312:201-211. doi: 10.1016/j.jconrel.2019.09.001. Shrestha R, DiDomizio EE, Kim RS, Altice FL, Wickersham JA, Copenhaver MM. HHS To date, women have been less represented than men in LA ART research. Investigators presented a case report of a second patient possibly cured of HIV through an allogeneic hematopoietic stem cell transplant from a CC chemokine receptor 5-delta 32 donor. Clipboard, Search History, and several other advanced features are temporarily unavailable. 2016 May-Jun;24(1):59-81. USA.gov. Ready for HIV Dual Therapy? Two clinical trials of long-acting injectable cabotegravir and rilpivirine showed promising safety, efficacy, and tolerability as maintenance ART. CROI 2018: Advances in Antiretroviral Therapy. Epub 2019 Sep 3. National Center for Biotechnology Information, Unable to load your collection due to an error, Unable to load your delegates due to an error. Likert scores of long-acting injectable antiretroviral therapy acceptability by proposed injection-site reaction duration. NIH With long-acting injectable antiretroviral therapy likely to be a treatment option for people living with HIV (PLWH), it is critical to assess its acceptability among potential end-users. Cabenuva, pending FDA approval, stands to impact HIV treatment in the U.S. Cabenuva would be the first injectable antiretroviral. Two clinical trials of long-acting injectable cabotegravir and rilpivirine showed promising safety, efficacy, and tolerability as maintenance ART. Please enable it to take advantage of the complete set of features! Olender S, Wilkin TJ, Taylor BS, Hammer SM. In appropriate combinations, it is so potent that plasma viral load is suppressed to levels undetectable by conventional assays. Theranostics. Hilaire JR, Bade AN, Sillman B, Gautam N, Herskovitz J, Dyavar Shetty BL, Wojtkiewicz MS, Szlachetka A, Lamberty BG, Sravanam S, Fox HS, Alnouti Y, Dash PK, McMillan JM, Edagwa BJ, Gendelman HE. CROI 2016: Advances in Antiretroviral Therapy. [Epub ahead of print] A Conjoint Analysis of the Acceptability of Targeted Long-Acting Injectable Antiretroviral Therapy Among Persons Living with HIV in the U.S. Simoni JM(1)(2), Tapia K(3), Lee SJ(4), Graham SM(3)(5), Beima-Sofie K(3), Mohamed ZH(3), Christodoulou J(4), Ho R(6), Collier AC(5). J Control Release. People who received a combination of two long-acting injectable antiretrovirals once a month expressed a high level of satisfaction with the regimen and almost all said they preferred it to their previous oral therapy, according to two studies presented yesterday at the 10th International AIDS Society Conference on HIV Science (IAS 2019) in Mexico City. 2020 Jan 1;10(2):630-656. doi: 10.7150/thno.39847. “ We found that long-acting injectable antiretroviral therapy was a compelling option among the women we interviewed.” The researchers conducted 59 in-depth interviews with women living with HIV in six Women’s Interagency HIV Study (WIHS) sites: New York, Chicago, Washington DC, Atlanta, Chapel Hill, and San Francisco, from November 2017 to October 2018. Published on Nov 22, 2019 The session outlines a study that evaluates Long Acting Injectable Antiretroviral Therapy (LA ART) as a solution to … Ready for HIV Dual Therapy? Would you like email updates of new search results?  |  The 2019 Conference on Retroviruses and Opportunistic Infections included many exciting advances in antiretroviral therapy (ART). USA.gov. First long-acting injectable antiretroviral therapy for HIV recommended for approval EMA has recommended the granting of marketing authorisations for two new antiretroviral (ARV) medicines, Rekambys (rilpivirine) and Vocabria injection (cabotegravir), to be used together for the treatment of patients with human immunodeficiency virus type 1 (HIV-1) infection. At baseline, half were taking NNRTI-based regimens, a third were taking integrase inhibitors and 17% were o… Chin Med J (Engl). Advances and challenges in antiretroviral therapy for acquired immunodeficiency syndrome. Shrestha R, DiDomizio EE, Kim RS, Altice FL, Wickersham JA, Copenhaver MM. Taylor BS, Olender SA, Tieu HV, Wilkin TJ. Based on the results of the phase 3 efficacy studies called ATLAS and FLAIR, we know that injectable CAB/RPV is safe, well-tolerated, and (among those who chose to participate in the studies), highly popular. Investigators presented a case report of a second patient possibly cured of HIV through an allogeneic hematopoietic stem cell transplant from a CC chemokine receptor 5-delta 32 donor. J Control Release. The data supporting a regimen consisting of injectable CAB/RPV were presented at CROI 2019 in the form of a pair of open-label trials named FLAIR and ATLAS. The ATLAS trial, presented by Swindells, included 616 treatment-experienced patients. COVID-19 is an emerging, rapidly evolving situation. Epub 2020 Jun 15. Epidemiologic data were reported on the prevalence, impact, regional variation, and changes over time of resistance-associated mutations. CROI 2018: Advances in Antiretroviral Therapy. Top Antivir Med. NIH Using in-depth interviews, this study sought to understand the experiences of PLHIV (n = 53) participating in Phase 3 LA ART trials in the United States and Spain. Long-acting injectable rilpivirine is not approved by … Long-acting (LA) injectable antiretroviral therapy (ART) has been found non-inferior to daily oral ART in Phase 3 trials. eCollection 2020. New findings were presented on maternal and fetal health outcomes in women of reproductive potential, drug-drug interactions between hormonal contraception and ART, and further exploration of the association between InSTIs and birth defects. The ATLAS-2M study examined reducing the frequency of dosing from 4-weekly to 8-weekly, the findings of which are reported by Edgar Overton and colleagues in The Lancet.1 They compared … - New Data from International HIV/AIDS Society 2017. In FLAIR, people who were treatment-naive were started on abacavir/dolutegravir/lamivudine (Triumeq) and, if they achieved viral suppression at 20 weeks, were randomized to either stay on this oral regimen or add oral CAB and RPV (to demonstrate … They had been on antiretroviral therapy for a median of four years, all had viral suppression and the median CD4 count was 653 cells/mm3. 2019 Oct;311-312:201-211. doi: 10.1016/j.jconrel.2019.09.001. NLM Two clinical trials of long-acting injectable cabotegravir and rilpivirine showed promising safety, efficacy, and tolerability as maintenance ART. 2019 Oct 26. doi: 10.1007/s10461-019-02701-7. - New Data from International HIV/AIDS Society 2017. and, for the combination of the long-acting rilpivirine and cabotegravir, provides an additional two-drug ART option. CROI 2014: Advances in antiretroviral therapy. In vitro studies were presented that identified and evaluated the effect of resistance-associated mutations on ART susceptibility and elucidated mechanisms of resistance. July 30, 2019. J Subst Abuse Treat.  |  Two studies done in Sub-Saharan Africa suggest that dolutegravir-based antiretroviral therapy is noninferior to efavirenz–based ART but is … CROI 2016: Advances in Antiretroviral Therapy. Creation of a long-acting rilpivirine prodrug nanoformulation. Get the latest public health information from CDC: https://www.coronavirus.gov, Get the latest research information from NIH: https://www.nih.gov/coronavirus, Find NCBI SARS-CoV-2 literature, sequence, and clinical content: https://www.ncbi.nlm.nih.gov/sars-cov-2/. Please enable it to take advantage of the complete set of features! Test-and-treat and rapid-ART-start strategies show promise in advancing progress toward the HIV care cascade 90-90-90 Joint United Nations Programme on HIV/AIDS/World Health Organization targets. Chin Med J (Engl). Among a list of presented options for primary preferred distribution venue for an injectable antiretroviral, a clear majority selected the clinician’s office (115, 57%) as their preferred venue. CROI 2014: Advances in antiretroviral therapy. Top Antivir Med. Test-and-treat and rapid-ART-start strategies show promise in advancing progress toward the HIV care cascade 90-90-90 Joint United Nations Programme on HIV/AIDS/World Health Organization targets. Decreasing regional and national rates of resistance may be a benefit of increasing use of integrase strand transfer inhibitors (InSTIs). Top Antivir Med. These delivery systems may give patients the ability to administer daily medica­tion less frequently and allow in-clinic admin­istration for those who have not disclosed their status and do not want to bring medi­cation bottles home. The study, called Long-Acting Therapy to Improve Treatment Success in Daily Life, or LATITUDE, will help determine whether a combination of two experimental injectable … 2020 Jan 1;10(2):630-656. doi: 10.7150/thno.39847. Antiretroviral therapy interrupts crucial steps of the HIV life cycle. LA ART may address key barriers to oral ART adherence and be preferable to daily pills for some people living with HIV. Creation of a long-acting rilpivirine prodrug nanoformulation. Carlos del Rio, MD reviewing N Engl J Med 2019 Jul 24 Venter WDF et al. Olender S, Wilkin TJ, Taylor BS, Hammer SM. More information: S. Rahima Benhabbour et al. Would you like email updates of new search results? Rod-shape theranostic nanoparticles facilitate antiretroviral drug biodistribution and activity in human immunodeficiency virus susceptible cells and tissues. Epub 2019 Sep 3. NLM Marketing Authorisation is based on the pivotal phase III ATLAS (Antiretroviral Therapy as Long-Acting Suppression), FLAIR (First Long-Acting Injectable Regimen) and ATLAS-2M studies, which included more than 1,200 participants from 16 countries. N Engl J Med 2019 Jul 24. Marketing Authorisation is based on the pivotal phase III ATLAS (Antiretroviral Therapy as Long-Acting Suppression), FLAIR (First Long-Acting Injectable Regimen) and ATLAS-2M studies, which included more than 1,200 participants from 16 countries. This strategy — two injections every 4 or 8 weeks — obviates the need to take antiretroviral therapy daily. A third were women, two thirds were white, about a quarter were black and the median age was 42 years. Long-acting injectable antiretroviral therapy (LA ART) may be an alternative for people living with HIV (PLHIV) with adherence challenges or who prefer not to take pills. Whilst ART does not cure HIV and AIDS, and should therefore be taken for life, it dramatically reduces mortality and morbidity if used appropriately. 2020 Oct;117:108058. doi: 10.1016/j.jsat.2020.108058. 2020 Dec 5;133(23):2775-2777. doi: 10.1097/CM9.0000000000001226. Long-acting injectable antiretroviral therapy (ART) offers the convenience of reduced dosing frequency and, for the combination of the long-acting rilpivirine and cabotegravir, provides an additional two-drug ART option. Taylor BS, Olender SA, Tieu HV, Wilkin TJ. eCollection 2020. Nucleoside reverse transcriptase inhibitors (NRTIs) are important components of antiretroviral therapy (ART) when combined with other medications [1, 2]. Epidemiologic data were reported on the prevalence, impact, regional variation, and changes over time of resistance-associated mutations.  |  Get the latest public health information from CDC: https://www.coronavirus.gov, Get the latest research information from NIH: https://www.nih.gov/coronavirus, Find NCBI SARS-CoV-2 literature, sequence, and clinical content: https://www.ncbi.nlm.nih.gov/sars-cov-2/. J Subst Abuse Treat. Advances in antiretroviral therapy ( ART ) has been reported across multiple settings Study. Wickersham JA, Copenhaver MM ; 10 ( 2 ):630-656. doi: 10.1097/CM9.0000000000001226 long-acting antiretroviral. Using longitudinal data from the women ’ S Interagency HIV Study ( )... Learn more about the new drug and what to consider ahead of its arrival! Over time of resistance-associated mutations United Nations Programme on HIV/AIDS/World Health Organization targets data from the women ’ Interagency! 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